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Target
Neutrophil elastase
Ligand
BDBM50060370
Substrate
n/a
Meas. Tech.
ChEMBL_63661 (CHEMBL675717)
IC50
280000±n/a nM
Citation
 Buynak, JD; Rao, AS; Ford, GP; Carver, C; Adam, G; Geng, B; Bachmann, B; Shobassy, S; Lackey, S 7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase. J Med Chem 40:3423-33 (1997) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50060370
Synonyms:
(S)-3-Acetoxymethyl-7-methoxy-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester | CHEMBL324743
Type:
Small organic molecule
Emp. Form.:
C24H23NO8S
Mol. Mass.:
485.506
SMILES:
CO[C@@H]1C2N(C1=O)C(C(=O)OC(c1ccccc1)c1ccccc1)=C(COC(C)=O)CS2(=O)=O |t:26|
Structure:
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