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Target
Neuropeptide Y receptor type 4
Ligand
BDBM50060724
Substrate
n/a
Meas. Tech.
ChEMBL_143981 (CHEMBL752581)
Ki
>10000±n/a nM
Citation
 Hipskind, PA; Lobb, KL; Nixon, JA; Britton, TC; Bruns, RF; Catlow, J; Dieckman-McGinty, DK; Gackenheimer, SL; Gitter, BD; Iyengar, S; Schober, DA; Simmons, RM; Swanson, S; Zarrinmayeh, H; Zimmerman, DM; Gehlert, DR Potent and selective 1,2,3-trisubstituted indole NPY Y-1 antagonists. J Med Chem 40:3712-4 (1997) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 4
Synonyms:
NPY-Y4 | NPY4-R | NPY4R | NPY4R_HUMAN | PP1 | PPYR1 | Pancreatic polypeptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42207.58
Organism:
Homo sapiens (Human)
Description:
NPY-Y4 PPYR1 HUMAN::P50391
Residue:
375
Sequence:
MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSNPI
  
Inhibitor
Name:
BDBM50060724
Synonyms:
2-[1,4']Bipiperidinyl-1'-yl-1-[2-(4-chloro-phenoxymethyl)-1-(2-piperidin-4-yl-ethyl)-1H-indol-3-yl]-ethanone | CHEMBL340369
Type:
Small organic molecule
Emp. Form.:
C34H45ClN4O2
Mol. Mass.:
577.2
SMILES:
Clc1ccc(OCc2c(C(=O)CN3CCC(CC3)N3CCCCC3)c3ccccc3n2CCC2CCNCC2)cc1
Structure:
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