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Target
5-lipoxygenase
Ligand
BDBM50060898
Substrate
n/a
Meas. Tech.
ChEMBL_157766 (CHEMBL767669)
IC50
3000±n/a nM
Citation
 Müller, K; Prinz, H; Gawlik, I; Ziereis, K; Huang, HS Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem 40:3773-80 (1997) [PubMed]  Article 
Target
Name:
5-lipoxygenase
Synonyms:
Arachidonate 5-lipoxygenase
Type:
PROTEIN
Mol. Mass.:
49994.23
Organism:
Bos taurus
Description:
ChEMBL_157766
Residue:
430
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGDIQLIKIEKRKYWFHDDWYLKYITVKTPCGDYIEFPCYRWISGEGEIVLRDGQAKLACDDQIHVLKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWSDFADFEKIFVRISNTISERVMNHWQEDRMFGYQFLNGCNPVMIQRCLKLPDNLPVTTEMVECSLERQLTLEQEIEQGNIFIVDFKLLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQVPGEENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGG
  
Inhibitor
Name:
BDBM50060898
Synonyms:
5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-1,4-dihydronaphthalene-1,4-dione (7a) | 5,8-dihydroxy-1,4-naphthoquinone | CHEMBL274056 | naphthazalin
Type:
Small organic molecule
Emp. Form.:
C10H6O4
Mol. Mass.:
190.1522
SMILES:
Oc1ccc(O)c2C(=O)C=CC(=O)c12 |c:9|
Structure:
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