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Target
Endothelin receptor type B
Ligand
BDBM50061073
Substrate
n/a
Meas. Tech.
ChEMBL_63872 (CHEMBL671334)
IC50
2.6±n/a nM
Citation
 Jae, HS; Winn, M; Dixon, DB; Marsh, KC; Nguyen, B; Opgenorth, TJ; von Geldern, TW Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonists. J Med Chem 40:3217-27 (1997) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_PIG | Endothelin receptor ET-B
Type:
PROTEIN
Mol. Mass.:
49616.89
Organism:
Sus scrofa
Description:
ChEMBL_63872
Residue:
443
Sequence:
MQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSNASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALGFDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50061073
Synonyms:
(2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(4-ethoxy-3-fluoro-phenyl)-1-{2-[(pentane-1-sulfonyl)-propyl-amino]-ethyl}-pyrrolidine-3-carboxylic acid | CHEMBL324639
Type:
Small organic molecule
Emp. Form.:
C30H41FN2O7S
Mol. Mass.:
592.719
SMILES:
CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1c1ccc(OCC)c(F)c1)C(O)=O)c1ccc2OCOc2c1
Structure:
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