Reaction Details Report a problem with these data
Target
Retinoic acid receptor RXR-gamma
Ligand
BDBM50061618
Substrate
n/a
Meas. Tech.
ChEMBL_196643 (CHEMBL800756)
Ki
620±n/a nM
Citation
 Umemiya, H; Fukasawa, H; Ebisawa, M; Eyrolles, L; Kawachi, E; Eisenmann, G; Gronemeyer, H; Hashimoto, Y; Shudo, K; Kagechika, H Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J Med Chem 40:4222-34 (1998) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-gamma
Synonyms:
NR2B3 | Nuclear receptor subfamily 2 group B member 3 | RXRG | RXRG_HUMAN | Retinoic acid receptor RXR-gamma | Retinoid X receptor gamma | Retinoid X receptor gamma/retinoic acid receptor alpha
Type:
PROTEIN
Mol. Mass.:
50878.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_197216
Residue:
463
Sequence:
MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
  
Inhibitor
Name:
BDBM50061618
Synonyms:
4-(7,7,10,10-Tetramethyl-7,8,9,10-tetrahydro-5-thia-13-aza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid | CHEMBL337859
Type:
Small organic molecule
Emp. Form.:
C28H27NO2S
Mol. Mass.:
441.584
SMILES:
CC1(C)CCC(C)(C)c2cc3c(Sc4ccccc4N=C3c3ccc(cc3)C(O)=O)cc12 |c:20|
Structure:
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