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Target
Kynurenine 3-monooxygenase
Ligand
BDBM50061918
Substrate
n/a
Meas. Tech.
ChEMBL_91740 (CHEMBL702202)
IC50
56±n/a nM
Citation
 Röver, S; Cesura, AM; Huguenin, P; Kettler, R; Szente, A Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem 40:4378-85 (1998) [PubMed]  Article 
Target
Name:
Kynurenine 3-monooxygenase
Synonyms:
KMO_RAT | Kmo
Type:
PROTEIN
Mol. Mass.:
54371.88
Organism:
Rattus norvegicus
Description:
ChEMBL_1487468
Residue:
478
Sequence:
MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
  
Inhibitor
Name:
BDBM50061918
Synonyms:
CHEMBL136265 | N-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-4-methyl-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C16H12Cl2N2O2S2
Mol. Mass.:
399.315
SMILES:
Cc1ccc(cc1)S(=O)(=O)Nc1nc(cs1)-c1ccc(Cl)c(Cl)c1
Structure:
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