Reaction Details Report a problem with these data
Target
Neutrophil collagenase
Ligand
BDBM50062322
Substrate
n/a
Meas. Tech.
ChEMBL_105205 (CHEMBL713844)
Ki
0.96±n/a nM
Citation
 Levy, DE; Lapierre, F; Liang, W; Ye, W; Lange, CW; Li, X; Grobelny, D; Casabonne, M; Tyrrell, D; Holme, K; Nadzan, A; Galardy, RE Matrix metalloproteinase inhibitors: a structure-activity study. J Med Chem 41:199-223 (1998) [PubMed]  Article 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50062322
Synonyms:
(R)-N*1*-((R)-1-Benzylcarbamoyl-2-pyridin-4-yl-ethyl)-N*4*-hydroxy-2-isobutyl-succinamide | CHEMBL69024
Type:
Small organic molecule
Emp. Form.:
C23H30N4O4
Mol. Mass.:
426.5087
SMILES:
CC(C)C[C@H](CC(=O)NO)C(=O)N[C@H](Cc1ccncc1)C(=O)NCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: