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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50063298
Substrate
n/a
Meas. Tech.
ChEMBL_1451 (CHEMBL616575)
Ki
76±n/a nM
Citation
 Wustrow, D; Belliotti, T; Glase, S; Kesten, SR; Johnson, D; Colbry, N; Rubin, R; Blackburn, A; Akunne, H; Corbin, A; Davis, MD; Georgic, L; Whetzel, S; Zoski, K; Heffner, T; Pugsley, T; Wise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem 41:760-71 (1998) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50063298
Synonyms:
(4-{2-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-pyrimidin-2-yl-amine | CHEMBL350352
Type:
Small organic molecule
Emp. Form.:
C22H29Cl2N5
Mol. Mass.:
434.405
SMILES:
Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)Nc3ncccn3)CC2)c1Cl |wU:15.18,wD:12.11,(19.11,-4.18,;18.42,-5.56,;19.28,-6.84,;18.57,-8.23,;17.04,-8.3,;16.21,-7.01,;14.66,-7.1,;13.82,-5.81,;12.29,-5.88,;11.59,-7.27,;10.04,-7.34,;9.2,-6.05,;7.66,-6.12,;6.82,-4.83,;5.29,-4.9,;4.57,-6.28,;5.42,-7.57,;6.96,-7.5,;3.03,-6.35,;2.19,-5.04,;.66,-5.13,;-.18,-3.82,;.52,-2.44,;2.07,-2.37,;2.91,-3.68,;12.43,-8.55,;13.98,-8.48,;16.89,-5.65,;16.04,-4.36,)|
Structure:
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