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Target
Complement C1r subcomponent
Ligand
BDBM50063697
Substrate
n/a
Meas. Tech.
ChEMBL_40165 (CHEMBL655960)
IC50
2000±n/a nM
Citation
 Hays, SJ; Caprathe, BW; Gilmore, JL; Amin, N; Emmerling, MR; Michael, W; Nadimpalli, R; Nath, R; Raser, KJ; Stafford, D; Watson, D; Wang, K; Jaen, JC 2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease. J Med Chem 41:1060-7 (1998) [PubMed]  Article 
Target
Name:
Complement C1r subcomponent
Synonyms:
C1R | C1R_HUMAN | Complement C1r | Complement C1r subcomponent
Type:
Enzyme
Mol. Mass.:
80113.65
Organism:
Homo sapiens (Human)
Description:
P00736
Residue:
705
Sequence:
MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDTHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED
  
Inhibitor
Name:
BDBM50063697
Synonyms:
2-(2,5-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4-one | CHEMBL274816
Type:
Small organic molecule
Emp. Form.:
C14H8Cl2N2O2
Mol. Mass.:
307.132
SMILES:
Clc1ccc(Cl)c(Nc2nc3ccccc3c(=O)o2)c1
Structure:
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