Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50063915
Substrate
n/a
Meas. Tech.
ChEMBL_105950 (CHEMBL715364)
IC50
0.3±n/a nM
Citation
Yamamoto, M; Tsujishita, H; Hori, N; Ohishi, Y; Inoue, S; Ikeda, S; Okada, Y Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket. J Med Chem 41:1209-17 (1998) [PubMed] Article
More Info.:
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Inhibitor
Name:
BDBM50063915
Synonyms:
(2R,3S)-N*4*-Hydroxy-2-isobutyl-3-methyl-N*1*-[(S)-1-methylcarbamoyl-2-(5,6,7,8-tetrahydro-naphthalen-1-yl)-ethyl]-succinamide | CHEMBL279078
Type:
Small organic molecule
Emp. Form.:
C23H35N3O4
Mol. Mass.:
417.5417
SMILES:
CNC(=O)[C@H](Cc1cccc2CCCCc12)NC(=O)[C@H](CC(C)C)[C@H](C)C(=O)NO