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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50064007
Substrate
n/a
Meas. Tech.
ChEMBL_196510 (CHEMBL798324)
IC50
77±n/a nM
Citation
 Wishka, DG; Graber, DR; Kopta, LA; Olmsted, RA; Friis, JM; Hosley, JD; Adams, WJ; Seest, EP; Castle, TM; Dolak, LA; Keiser, BJ; Yagi, Y; Jeganathan, A; Schlachter, ST; Murphy, MJ; Cleek, GJ; Nugent, RA; Poppe, SM; Swaney, SM; Han, F; Watt, W; White, WL; Poel, TJ; Thomas, RC; Morris, J (-)-6-Chloro-2-[(1-furo[2, 3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor. J Med Chem 41:1357-60 (1998) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50064007
Synonyms:
6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANYL)-PYRIMIDIN-4-YLAMINE | 6-Chloro-2-((S)-1-furo[2,3-c]pyridin-5-yl-ethylsulfanyl)-pyrimidin-4-ylamine | CHEMBL280541 | PNU-142721
Type:
Small organic molecule
Emp. Form.:
C13H11ClN4OS
Mol. Mass.:
306.771
SMILES:
C[C@H](Sc1nc(N)cc(Cl)n1)c1cc2ccoc2cn1
Structure:
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