Reaction Details Report a problem with these data
Target
Retinoic acid receptor beta
Ligand
BDBM50064255
Substrate
n/a
Meas. Tech.
ChEMBL_195641 (CHEMBL795959)
IC50
>1000±n/a nM
Citation
 Muccio, DD; Brouillette, WJ; Breitman, TR; Taimi, M; Emanuel, PD; Zhang, X; Chen, G; Sani, BP; Venepally, P; Reddy, L; Alam, M; Simpson-Herren, L; Hill, DL Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias. J Med Chem 41:1679-87 (1998) [PubMed]  Article 
Target
Name:
Retinoic acid receptor beta
Synonyms:
Nr1b2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RARB_MOUSE | Rarb
Type:
PROTEIN
Mol. Mass.:
53344.93
Organism:
Mus musculus
Description:
ChEMBL_195641
Residue:
482
Sequence:
MSTSSHACPVPAVRGHMTHYPAAPYPLLFPPVIRGLSLPPLHGLHGHPPPSGCSTPSPASVGQACQRTTGGSQFAASTKWTPSLNAAIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNIAEHSPSVSPSSVENSGVSQSPLLQ
  
Inhibitor
Name:
BDBM50064255
Synonyms:
(2E,4Z,6Z)-8-[3-Ethyl-2-isopropyl-cyclohex-2-en-(E)-ylidene]-3,7-dimethyl-octa-2,4,6-trienoic acid | CHEMBL43833
Type:
Small organic molecule
Emp. Form.:
C21H30O2
Mol. Mass.:
314.4617
SMILES:
CCC1=C(C(C)C)\C(CCC1)=C\C(\C)=C/C=C\C(\C)=C\C(O)=O |c:2|
Structure:
Search PDB for entries with ligand similarity: