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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM177
Substrate
n/a
Meas. Tech.
ChEMBL_157717 (CHEMBL763391)
Ki
0.01±n/a nM
Citation
 Han, Q; Chang, CH; Li, R; Ru, Y; Jadhav, PK; Lam, PY Cyclic HIV protease inhibitors: design and synthesis of orally bioavailable, pyrazole P2/P2' cyclic ureas with improved potency. J Med Chem 41:2019-28 (1998) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM177
Synonyms:
(4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis({3-[(hydroxyimino)methyl]phenyl}methyl)-1,3-diazepan-2-one | CHEMBL305125 | Cyclic Urea
Type:
n/a
Emp. Form.:
C35H36N4O5
Mol. Mass.:
592.6841
SMILES:
O[C@@H]1[C@@H](O)[C@@H](Cc2ccccc2)N(Cc2cccc(CN=O)c2)C(=O)N(Cc2cccc(CN=O)c2)[C@@H]1Cc1ccccc1
Structure:
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