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TargetHuman immunodeficiency virus type 1 protease
LigandBDBM50065071
Substrate/Competitorn/a
Meas. Tech.ChEMBL_157733
Ki 0.022±n/a nM
Citation De Lucca, GVKim, UTLiang, JCordova, BKlabe, RMGarber, SBacheler, LTLam, GNWright, MRLogue, KAErickson-Viitanen, SKo, SSTrainor, GL Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues. J Med Chem41:2411-23 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 protease
Name:Human immunodeficiency virus type 1 protease
Synonyms:Pol polyprotein
Type:Enzyme Subunit
Mol. Mass.:10781.16
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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  Blast E-value cutoff:
BDBM50065071
NameBDBM50065071
Synonyms:(4R,5S,6S,7R)-4,7-Dibenzyl-5,6-dihydroxy-1-(1H-indazol-5-ylmethyl)-3-[3-(2-[1,2,4]triazol-1-yl-acetyl)-benzyl]-[1,3]diazepan-2-one | CHEMBL312349
TypeSmall organic molecule
Emp. Form.C38H37N7O4
Mol. Mass.655.7449
SMILESO[C@@H]1[C@@H](O)[C@@H](Cc2ccccc2)N(Cc2ccc3[nH]ncc3c2)C(=O)N(Cc2cccc(c2)C(=O)Cn2cncn2)[C@@H]1Cc1ccccc1
Structure
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