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Target
Epidermal growth factor receptor
Ligand
BDBM50066984
Substrate
n/a
Meas. Tech.
ChEMBL_66886 (CHEMBL675510)
IC50
11300±n/a nM
Citation
 Copp, BR; Fairchild, CR; Cornell, L; Casazza, AM; Robinson, S; Ireland, CM Naamidine A is an antagonist of the epidermal growth factor receptor and an in vivo active antitumor agent. J Med Chem 41:3909-11 (1998) [PubMed]  Article 
Target
Name:
Epidermal growth factor receptor
Synonyms:
EGFR_MOUSE | Egfr | Epidermal growth factor receptor erbB1
Type:
PROTEIN
Mol. Mass.:
134859.02
Organism:
Mus musculus
Description:
ChEMBL_305656
Residue:
1210
Sequence:
MRPSGTARTTLLVLLTALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMYNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICAQQCSHRCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSATSNNSTVACINRNGSCRVKEDAFLQRYSSDPTGAVTEDNIDDAFLPVPEYVNQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVGNPEYLNTAQPTCLSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKETKPNGIFKGPTAENAEYLRVAPPSSEFIGA
  
Inhibitor
Name:
BDBM50066984
Synonyms:
4-(5-(4-hydroxybenzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-ylamino)-1-methyl-1H-imidazole-2,5-dione | 5-[5-(4-Hydroxy-benzyl)-4-(4-methoxy-benzyl)-1-methyl-1H-imidazol-2-ylamino]-3-methyl-imidazole-2,4-dione | CHEMBL339727
Type:
Small organic molecule
Emp. Form.:
C23H23N5O4
Mol. Mass.:
433.4598
SMILES:
COc1ccc(Cc2nc(NC3=NC(=O)N(C)C3=O)n(C)c2Cc2ccc(O)cc2)cc1 |t:11|
Structure:
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