Reaction Details Report a problem with these data
Target
Apoptosis regulator BAX
Ligand
BDBM50516397
Substrate
n/a
Meas. Tech.
ChEMBL_1865096 (CHEMBL4366071)
IC50
43±n/a nM
Citation
 Liu, G; Yin, T; Kim, H; Ding, C; Yu, Z; Wang, H; Chen, H; Yan, R; Wold, EA; Zou, H; Liu, X; Ding, Y; Shen, Q; Zhou, J Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer. Eur J Med Chem 178:589-605 (2019) [PubMed]  Article 
Target
Name:
Apoptosis regulator BAX
Synonyms:
Apoptosis regulator BAX | BAX | BAX_HUMAN | BCL2L4 | Bcl-2-like protein 4 | Bcl2-L-4
Type:
PROTEIN
Mol. Mass.:
21181.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100916
Residue:
192
Sequence:
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
  
Inhibitor
Name:
BDBM50516397
Synonyms:
CHEMBL4579601
Type:
Small organic molecule
Emp. Form.:
C20H13NO3
Mol. Mass.:
315.3221
SMILES:
Oc1ccccc1C=C1c2ccccc2-c2ccc(cc12)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: