Target
Stromelysin-1
Ligand
BDBM50071264
Substrate
n/a
Meas. Tech.
ChEBML_101938
IC50
12±n/a nM
Citation
 Steinman, DHCurtin, MLGarland, RBDavidsen, SKHeyman, HRHolms, JHAlbert, DHMagoc, TJNagy, IBMarcotte, PALi, JMorgan, DWHutchins, CSummers, JB The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors. Bioorg Med Chem Lett 8:2087-92 (1999) [PubMed]  Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50071264
Synonyms:
(9S,10R,13S)-10-Isobutyl-11-oxo-2-oxa-12-aza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-triene-9,13-dicarboxylic acid 9-hydroxyamide 13-methylamide | CHEMBL293003
Type:
Small organic molecule
Emp. Form.:
C24H37N3O5
Mol. Mass.:
447.5677
SMILES:
CNC(=O)[C@@H]1Cc2ccc(OCCCCCC[C@@H]([C@@H](CC(C)C)C(=O)N1)C(=O)NO)cc2
Structure:
Search PDB for entries with ligand similarity: