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Target
Histamine H3 receptor
Ligand
BDBM50071344
Substrate
n/a
Meas. Tech.
ChEMBL_85850 (CHEMBL693577)
Ki
10±n/a nM
Citation
 Wolin, R; Connolly, M; Afonso, A; Hey, JA; She, H; Rivelli, MA; Willams, SM; West, RE Novel H3 receptor antagonists. Sulfonamide homologs of histamine. Bioorg Med Chem Lett 8:2157-62 (1999) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
GUINEA PIG
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50071344
Synonyms:
CHEMBL71592 | N-[4-(1H-Imidazol-4-yl)-butyl]-4-trifluoromethyl-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C14H16F3N3O2S
Mol. Mass.:
347.356
SMILES:
FC(F)(F)c1ccc(cc1)S(=O)(=O)NCCCCc1cnc[nH]1
Structure:
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