Reaction Details Report a problem with these data
Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50071633
Substrate
n/a
Meas. Tech.
ChEBML_99856
IC50
0.400000±n/a nM
Citation
Brown, MF; Marfat, A; Antognoli, G; Chambers, RJ; Cheng, JB; Damon, DB; Liston, TE; McGlynn, MA; O'Sullivan, SP; Owens, BS; Pillar, JS; Shirley, JT; Watson, JW N-carbamoyl analogs of Zafirlukast: potent receptor antagonists of leukotriene D4. Bioorg Med Chem Lett 8:2451-6 (1999) [PubMed] Article
More Info.:
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
Inhibitor
Name:
BDBM50071633
Synonyms:
CHEMBL83166 | [3-[2-Methoxy-4-(toluene-2-sulfonylaminocarbonyl)-benzyl]-1-(morpholine-4-carbonyl)-1H-indol-5-yl]-carbamic acid cyclopentyl ester
Type:
Small organic molecule
Emp. Form.:
C35H38N4O8S
Mol. Mass.:
674.763
SMILES:
COc1cc(ccc1Cc1cn(C(=O)N2CCOCC2)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C