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Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50072394
Substrate
n/a
Meas. Tech.
ChEMBL_210510 (CHEMBL811905)
Ki
23±n/a nM
Citation
 Chu, W; Perlman, JH; Gershengorn, MC; Moeller, KD Thyrotropin releasing hormone analogs: a building block approach to the construction of tetracyclic peptidomimetics. Bioorg Med Chem Lett 8:3093-6 (1999) [PubMed]  Article 
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
TRH-R | TRHR_MOUSE | Thyroliberin receptor | Trhr | thyrotropin-releasing hormone R1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44568.52
Organism:
MOUSE
Description:
thyrotropin-releasing hormone R1 TRHR MOUSE::P21761
Residue:
393
Sequence:
MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
  
Inhibitor
Name:
BDBM50072394
Synonyms:
1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyrrolylcarboxamido)propanoyl]tetrahydro-1H-2-pyrrolecarboxamide | A-38579 | ABBOTT-38579 | PROTIRELIN
Type:
Small organic molecule
Emp. Form.:
C16H22N6O4
Mol. Mass.:
362.3837
SMILES:
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Structure:
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