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Target
Matrilysin
Ligand
BDBM50072569
Substrate
n/a
Meas. Tech.
ChEBML_102124
IC50
4.2±n/a nM
Citation
 Sheppard, GS; Florjancic, AS; Giesler, JR; Xu, L; Guo, Y; Davidsen, SK; Marcotte, PA; Elmore, I; Albert, DH; Magoc, TJ; Bouska, JJ; Goodfellow, CL; Morgan, DW; Summers, JB Aryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors. Bioorg Med Chem Lett 8:3251-6 (1999) [PubMed]  Article 
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM50072569
Synonyms:
(2R,3S)-2-Allyl-N*4*-((S)-1-benzyl-2-oxazol-2-yl-2-oxo-ethyl)-N*1*-hydroxy-3-isobutyl-succinamide | (2S,3R)-2-allyl-N1-hydroxy-3-isobutyl-N4-((S)-1-(oxazol-2-yl)-1-oxo-3-phenylpropan-2-yl)succinamide | CHEMBL430524
Type:
Small organic molecule
Emp. Form.:
C23H29N3O5
Mol. Mass.:
427.4935
SMILES:
CC(C)C[C@H]([C@H](CC=C)C(=O)NO)C(=O)N[C@@H](Cc1ccccc1)C(=O)c1ncco1
Structure:
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