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Target
ATP-dependent Clp protease proteolytic subunit
Ligand
BDBM50518619
Substrate
n/a
Meas. Tech.
ChEMBL_1872034 (CHEMBL4373201)
IC50
8200±n/a nM
Citation
 Moreno-Cinos, C; Sassetti, E; Salado, IG; Witt, G; Benramdane, S; Reinhardt, L; Cruz, CD; Joossens, J; Van der Veken, P; Brötz-Oesterhelt, H; Tammela, P; Winterhalter, M; Gribbon, P; Windshügel, B; Augustyns, K ?-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease. J Med Chem 62:774-797 (2019) [PubMed]  Article 
Target
Name:
ATP-dependent Clp protease proteolytic subunit
Synonyms:
ATP-dependent Clp protease proteolytic subunit | CLPP_ECOLI | Caseinolytic protease | Endopeptidase Clp | Heat shock protein F21.5 | JW0427 | Protease Ti | clpP | lopP
Type:
PROTEIN
Mol. Mass.:
23183.39
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_109492
Residue:
207
Sequence:
MSYSGERDNFAPHMALVPMVIEQTSRGERSFDIYSRLLKERVIFLTGQVEDHMANLIVAQMLFLEAENPEKDIYLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQAASMGAFLLTAGAKGKRFCLPNSRVMIHQPLGGYQGQATDIEIHAREILKVKGRMNELMALHTGQSLEQIERDTERDRFLSAPEAVEYGLVDSILTHRN
  
Inhibitor
Name:
BDBM50518619
Synonyms:
CHEMBL4575669
Type:
Small organic molecule
Emp. Form.:
C30H24F3N2O8P
Mol. Mass.:
628.4891
SMILES:
FC(F)(F)C(=O)Nc1ccc(cc1)C(NC(=O)OCc1ccc2OCOc2c1)P(=O)(Oc1ccccc1)Oc1ccccc1
Structure:
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