Reaction Details Report a problem with these data
Target
Potassium-transporting ATPase subunit beta
Ligand
BDBM50073332
Substrate
n/a
Meas. Tech.
ChEBML_29657
IC50
27±n/a nM
Citation
Nadler, G; Morvan, M; Delimoge, I; Belfiore, P; Zocchetti, A; James, I; Zembryki, D; Lee-Rycakzewski, E; Parini, C; Consolandi, E; Gagliardi, S; Farina, C (2Z,4E)-5-(5,6-dichloro-2-indolyl)-2-methoxy-N-(1,2,2,6,6- pentamethylpiperidin-4-yl)-2,4-pentadienamide, a novel, potent and selective inhibitor of the osteoclast V-ATPase. Bioorg Med Chem Lett 8:3621-6 (1999) [PubMed] Article
More Info.:
Target
Name:
Potassium-transporting ATPase subunit beta
Synonyms:
ATP4B | ATP4B_PIG | Gastric H(+)/K(+) ATPase subunit beta | Potassium-transporting ATPase | Potassium-transporting ATPase beta chain | Potassium-transporting ATPase subunit beta | Proton pump beta chain | gp60-90
Type:
n/a
Mol. Mass.:
33083.09
Organism:
Sus scrofa (Pig)
Description:
n/a
Residue:
290
Sequence:
MAALQEKKSCSQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMSGIFALCIYVLMRTIDPYTPDYQDQLKSPGVTLRPDVYGEKGLDISYNVSDSTTWAGLAHTLHRFLAGYSPAAQEGSINCTSEKYFFQESFLAPNHTKFSCKFTADMLQNCSGRPDPTFGFAEGKPCFIIKMNRIVKFLPGNSTAPRVDCAFLDQPRDGPPLQVEYFPANGTYSLHYFPYYGKKAQPHYSNPLVAAKLLNVPRNRDVVIVCKILAEHVSFDNPHDPYEGKVEFKLKIQK
Inhibitor
Name:
BDBM50073332
Synonyms:
(2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-penta-2,4-dienoic acid (1,2,2,6,6-pentamethyl-piperidin-4-yl)-amide | CHEMBL434032
Type:
Small organic molecule
Emp. Form.:
C24H31Cl2N3O2
Mol. Mass.:
464.428
SMILES:
CO\C(=C/C=C/c1cc2cc(Cl)c(Cl)cc2[nH]1)C(=O)NC1CC(C)(C)N(C)C(C)(C)C1