Reaction Details Report a problem with these data
Target
Calpain-1 catalytic subunit
Ligand
BDBM50073849
Substrate
n/a
Meas. Tech.
ChEBML_43477
Ki
45000±n/a nM
Citation
 Angelastro, MR; Marquart, AL; Mehdi, S; Koehl, JR; Vaz, RJ; Bey, P; Peet, NP The synthesis of ketomethylene pseudopeptide analogues of dipeptide aldehyde inhibitors of calpain. Bioorg Med Chem Lett 9:139-40 (1999) [PubMed]  Article 
Target
Name:
Calpain-1 catalytic subunit
Synonyms:
CANP | CANX_CHICK | Calcium-activated neutral proteinase | Calpain 1/2 | Calpain-1 catalytic subunit | Calpain-1 large subunit | Mu/M-type
Type:
PROTEIN
Mol. Mass.:
80319.95
Organism:
Gallus gallus
Description:
ChEMBL_43477
Residue:
705
Sequence:
MMPFGGIAARLQRDRLRAEGVGEHNNAVKYLNQDYEALKQECIESGTLFRDPQFPAGPTALGFKELGPYSSKTRGVEWKRPSELVDDPQFIVGGATRTDICQGALGDCWLLAAIGSLTLNEELLHRVVPHGQSFQEDYAGIFHFQIWQFGEWVDVVVDDLLPTKDGELLFVHSAECTEFWSALLEKAYAKLNGCYESLSGGSTTEGFEDFTGGVAEMYDLKRAPRNMGHIIRKALERGSLLGCSIDITSAFDMEAVTFKKLVKGHAYSVTAFKDVNYRGQQEQLIRIRNPWGQVEWTGAWSDGSSEWDNIDPSDREELQLKMEDGEFWMSFRDFMREFSRLEICNLTPDALTKDELSRWHTQVFEGTWRRGSTAGGCRNNPATFWINPQFKIKLLEEDDDPGDDEVACSFLVALMQKHRRRERRVGGDMHTIGFAVYEVPEEAQGSQNVHLKKDFFLRNQSRARSETFINLREVSNQIRLPPGEYIVVPSTFEPHKEADFILRVFTEKQSDTAELDEEISADLADEEEITEDDIEDGFKNMFQQLAGEDMEISVFELKTILNRVIARHKDLKTDGFSLDSCRNMVNLMDKDGSARLGLVEFQILWNKIRSWLTIFRQYDLDKSGTMSSYEMRMALESAGFKLNNKLHQVVVARYADAETGVDFDNFVCCLVKLETMFRFFHSMDRDGTGTAVMNLAEWLLLTMCG
  
Inhibitor
Name:
BDBM50073849
Synonyms:
((S)-1-Isopropyl-4-methyl-2,5-dioxo-pentyl)-carbamic acid benzyl ester | CHEMBL31728
Type:
Small organic molecule
Emp. Form.:
C17H23NO4
Mol. Mass.:
305.3688
SMILES:
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)CC(C)C=O
Structure:
Search PDB for entries with ligand similarity: