Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50073918
Substrate
n/a
Meas. Tech.
ChEBML_66902
IC50
1.2±n/a nM
Citation
 Schoepfer, J; Fretz, H; Gay, B; Furet, P; García-Echeverría, C; End, N; Caravatti, G Highly potent inhibitors of the Grb2-SH2 domain. Bioorg Med Chem Lett 9:221-6 (1999) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50073918
Synonyms:
CHEMBL431982 | [4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-indol-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-benzyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C34H45N6O8P
Mol. Mass.:
696.7303
SMILES:
CC(=O)N[C@@H](Cc1ccc(CP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCn1ccc2ccccc12
Structure:
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