Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50074087
Substrate
n/a
Meas. Tech.
ChEMBL_86761 (CHEMBL698661)
Ki
20±n/a nM
Citation
 Sasse, A; Kiec-Kononowicz, K; Stark, H; Motyl, M; Reidemeister, S; Ganellin, CR; Ligneau, X; Schwartz, JC; Schunack, W Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity. J Med Chem 42:593-600 (1999) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50074087
Synonyms:
CHEMBL1076266 | CHEMBL157493 | sec-Butyl-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester; compound with (E)-but-2-enedioic acid
Type:
Small organic molecule
Emp. Form.:
C11H19N3O2
Mol. Mass.:
225.2875
SMILES:
CCC(C)NC(=O)OCCCc1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity: