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Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50060433
Substrate
n/a
Meas. Tech.
ChEMBL_1616 (CHEMBL616641)
IC50
570±n/a nM
Citation
 Sternfeld, F; Guiblin, AR; Jelley, RA; Matassa, VG; Reeve, AJ; Hunt, PA; Beer, MS; Heald, A; Stanton, JA; Sohal, B; Watt, AP; Street, LJ Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor. J Med Chem 42:677-90 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50060433
Synonyms:
3-(2-Piperidin-1-yl-ethyl)-5-[1,2,4]triazol-4-yl-1H-indole | CHEMBL330803
Type:
Small organic molecule
Emp. Form.:
C17H21N5
Mol. Mass.:
295.3821
SMILES:
C(Cc1c[nH]c2ccc(cc12)-n1cnnc1)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: