Reaction Details Report a problem with these data
Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM50074951
Substrate
n/a
Meas. Tech.
ChEBML_212262
IC50
200±n/a nM
Citation
 Chen, MH; Steiner, MG; de Laszlo, SE; Patchett, AA; Anderson, MS; Hyland, SA; Onishi, HR; Silver, LL; Raetz, CR Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis. Bioorg Med Chem Lett 9:313-8 (1999) [PubMed]  Article 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC
Type:
Enzyme
Mol. Mass.:
33952.00
Organism:
Escherichia coli
Description:
P0A725
Residue:
305
Sequence:
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
  
Inhibitor
Name:
BDBM50074951
Synonyms:
(R)-2-(4-Ethyl-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid hydroxyamide | CHEMBL110810
Type:
Small organic molecule
Emp. Form.:
C12H14N2O3
Mol. Mass.:
234.2512
SMILES:
CCc1ccc(cc1)C1=N[C@H](CO1)C(=O)NO |t:9|
Structure:
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