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Target
Capsid scaffolding protein
Ligand
BDBM50075138
Substrate
n/a
Meas. Tech.
ChEBML_161075
IC50
17±n/a nM
Citation
 Jarvest, RL; Pinto, IL; Ashman, SM; Dabrowski, CE; Fernandez, AV; Jennings, LJ; Lavery, P; Tew, DG Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones. Bioorg Med Chem Lett 9:443-8 (1999) [PubMed]  Article 
Target
Name:
Capsid scaffolding protein
Synonyms:
0R | Human herpesvirus 6 protease | SCAF_HHV6U | U53 | XKRF1
Type:
PROTEIN
Mol. Mass.:
58627.41
Organism:
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human Blymphotropic virus)
Description:
ChEMBL_161075
Residue:
528
Sequence:
MSKVWVGGFLCVYGEEPSEECLALPRDTVQKELGSGNIPLPLNINHNEKATIGMVRGLFDLEHGLFCVAQIQSQTFMDIIRNIAGKSKLITAGSVIEPLPPDPEIECLSSSFPGLSLSSKVLQDENLDGKPFFHHVSVCGVGRRPGTIAIFGREISWILDRFSCISESEKRQVLEGVNVYSQGFDENLFSADLYDLLADSLDTSYIRKRFPKLQLDKQLCGLSKCTYIKASEPPVEIIVAATKVAGDQVQLTTEPGSELAVETCDVPVVHGNYDAVESATATTAMSNQNLPNTTPLLSSPPFSDCVFLPKDAFFSLLNVTTGQQPKIVPPVSVHPPVTEQYQMLPYSESAAKIAEHESNRYHSPCQAMYPYWQYSPVPQYPAALHGYRQSKTLKKRHFQSDSEDELSFPGDPEYTKKRRRHRVDNDDDKEMAREKNDLRELVDMIGMLRQEISALKHVRAQSPQRHIVPMETLPTIEEKGAASPKPSILNASLAPETVNRSLAGQNESTDLLKLNKKLFVDALNKMDS
  
Inhibitor
Name:
BDBM50075138
Synonyms:
(E)-3-(5-Chloro-thiophen-2-yl)-N-[(S)-1-(5-methyl-4-oxo-4H-thieno[2,3-d][1,3]oxazin-2-yl)-ethyl]-acrylamide | CHEMBL343931
Type:
Small organic molecule
Emp. Form.:
C16H13ClN2O3S2
Mol. Mass.:
380.869
SMILES:
C[C@H](NC(=O)\C=C\c1ccc(Cl)s1)c1nc2scc(C)c2c(=O)o1
Structure:
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