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Target
cGMP-specific 3',5'-cyclic phosphodiesterase
Ligand
BDBM50066454
Substrate
n/a
Meas. Tech.
ChEMBL_155193 (CHEMBL763666)
IC50
1.6±n/a nM
Citation
 Ukita, T; Nakamura, Y; Kubo, A; Yamamoto, Y; Takahashi, M; Kotera, J; Ikeo, T 1-Arylnaphthalene lignan: a novel scaffold for type 5 phosphodiesterase inhibitor. J Med Chem 42:1293-305 (1999) [PubMed]  Article 
Target
Name:
cGMP-specific 3',5'-cyclic phosphodiesterase
Synonyms:
CGB-PDE | PDE5 | PDE5A | PDE5A_CANLF | Phosphodiesterase 5A | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3',5'-cyclic phosphodiesterase
Type:
PROTEIN
Mol. Mass.:
98285.03
Organism:
Canis lupus familiaris
Description:
ChEMBL_105565
Residue:
865
Sequence:
MERGSPGAGAARLPRDQDSVEAWLDDHRDFTFSYFVKKATREMVNAWFAERVHTIPVCKEGIRGHAESCSCSSQQSSRADSSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLADSEKKEQMPLTPPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKLPDTLTRERDANRINYMYAQYVKNTMEPLNIPDVSKDKRFPWTNENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETKELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKTLINGESSQAKRN
  
Inhibitor
Name:
BDBM50066454
Synonyms:
CHEMBL25616 | Sodium; 1-{4-[(benzo[1,3]dioxol-5-ylmethyl)-amino]-6-chloro-quinazolin-2-yl}-piperidine-4-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H20ClN4O4
Mol. Mass.:
439.872
SMILES:
[O-]C(=O)C1CCN(CC1)c1nc(NCc2ccc3OCOc3c2)c2cc(Cl)ccc2n1
Structure:
Search PDB for entries with ligand similarity: