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Target
Presenilin-1
Ligand
BDBM50521243
Substrate
n/a
Meas. Tech.
ChEMBL_1883816 (CHEMBL4385315)
EC50
0.005900±n/a nM
Citation
 Blass, BE Bridged Piperidine Derivatives Useful as ?-Secretase Inhibitors for the Treatment of Alzheimer's Disease. ACS Med Chem Lett 10:6-7 (2019) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50521243
Synonyms:
CHEMBL4532868
Type:
Small organic molecule
Emp. Form.:
C23H24ClF2N7
Mol. Mass.:
471.933
SMILES:
[H][C@]12CC[C@]([H])(CN(C1)c1ccnc(Cl)c1)[C@H]2Nc1nc2N(CCCn2n1)c1ccc(F)c(F)c1 |r,TLB:17:16:3.2:6.8.7,THB:9:7:3.2:16|
Structure:
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