Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily KQT member 4
Ligand
BDBM50143558
Substrate
n/a
Meas. Tech.
ChEMBL_1883897 (CHEMBL4385396)
EC50
5900±n/a nM
Citation
 Wang, L; Qiao, GH; Hu, HN; Gao, ZB; Nan, FJ Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity. ACS Med Chem Lett 10:27-33 (2019) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 4
Synonyms:
KCNQ (Kv7) potassium channel | KCNQ4 | KCNQ4_HUMAN | KQT-like 4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4
Type:
PROTEIN
Mol. Mass.:
77131.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1520985
Residue:
695
Sequence:
MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
  
Inhibitor
Name:
BDBM50143558
Synonyms:
CHEMBL41355 | EZOGABINE | N-(2-amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethylester | RETIGABINE | [2-Amino-4-(4-fluoro-benzylamino)-phenyl]-carbamic acid ethyl ester
Type:
Small organic molecule
Emp. Form.:
C16H18FN3O2
Mol. Mass.:
303.3314
SMILES:
CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N
Structure:
Search PDB for entries with ligand similarity: