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Target
Serine protease 1
Ligand
BDBM50076066
Substrate
n/a
Meas. Tech.
ChEBML_212700
IC50
479±n/a nM
Citation
 Reiner, JE; Lim-Wilby, MS; Brunck, TK; Ha-Uong, T; Goldman, EA; Abelman, MA; Nutt, RF; Semple, JE; Tamura, SY Investigation of the S3 site of thrombin: design, synthesis and biological activity of 4-substituted 3-amino-2-pyridones incorporating P1-argininals. Bioorg Med Chem Lett 9:895-900 (1999) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50076066
Synonyms:
1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro-5-pyridinyl]-2-[3-methylsulfonamido-2-oxo-4-(3-phenylpropyl)-1,2-dihydro-1-pyridinyl]acetamide | CHEMBL170400
Type:
Small organic molecule
Emp. Form.:
C23H32N6O5S
Mol. Mass.:
504.602
SMILES:
CS(=O)(=O)Nc1c(CCCc2ccccc2)ccn(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O
Structure:
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