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Target
Prothrombin
Ligand
BDBM50076511
Substrate
n/a
Meas. Tech.
ChEMBL_208364 (CHEMBL813674)
Ki
2±n/a nM
Citation
 Bachand, B; DiMaio, J; Siddiqui, MA Synthesis and structure-activity relationship of potent bicyclic lactam thrombin inhibitors. Bioorg Med Chem Lett 9:913-8 (1999) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50076511
Synonyms:
(3R,6R,8aS)-8a-Methyl-5-oxo-6-(3-phenyl-propyl)-hexahydro-thiazolo[3,2-a]pyridine-3-carboxylic acid [4-guanidino-1-(thiazole-2-carbonyl)-butyl]-amide; HCl | CHEMBL352392
Type:
Small organic molecule
Emp. Form.:
C27H37N6O3S2
Mol. Mass.:
557.751
SMILES:
C[C@]12CC[C@@H](CCCc3ccccc3)C(=O)N1[C@@H](CS2)C(=O)NC(CCCNC([NH3+])=N)C(=O)c1nccs1
Structure:
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