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Target
Xaa-Pro aminopeptidase 1
Ligand
BDBM50078393
Substrate
n/a
Meas. Tech.
ChEMBL_35519 (CHEMBL644752)
IC50
2700±n/a nM
Citation
 Maggiora, LL; Orawski, AT; Simmons, WH Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem 42:2394-402 (1999) [PubMed]  Article 
Target
Name:
Xaa-Pro aminopeptidase 1
Synonyms:
Aminoacylproline aminopeptidase | Cytosolic aminopeptidase P | Soluble aminopeptidase P | X-Pro aminopeptidase 1 | X-prolyl aminopeptidase 1, soluble | XPNPEP1 | XPNPEPL | XPNPEPL1 | XPP1_HUMAN | sAmp
Type:
PROTEIN
Mol. Mass.:
69905.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_461054
Residue:
623
Sequence:
MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGDRIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSETIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKELQKQGRQEALEWLIRETQPISKQH
  
Inhibitor
Name:
BDBM50078393
Synonyms:
(S)-1-[(S)-1-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-butyryl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carboxylic acid {(S)-1-[(S)-1-((R)-1-carbamoyl-2-mercapto-ethylcarbamoyl)-ethylcarbamoyl]-ethyl}-amide | CHEMBL78505
Type:
Small organic molecule
Emp. Form.:
C29H43N7O7S
Mol. Mass.:
633.759
SMILES:
C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](CS)C(N)=O
Structure:
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