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Target
Prothrombin
Ligand
BDBM50078551
Substrate
n/a
Meas. Tech.
ChEBML_208128
IC50
3200±n/a nM
Citation
 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Thrombin inhibitors based on [5,5] trans-fused indane lactams. Bioorg Med Chem Lett 9:1657-62 (1999) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50078551
Synonyms:
CHEMBL46365 | [(3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethylcarbamoyl-phenyl)-2-oxo-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]pyrrol-1-yl]-phosphonic acid diethyl ester
Type:
Small organic molecule
Emp. Form.:
C31H43N4O5P
Mol. Mass.:
582.6707
SMILES:
CCOP(=O)(OCC)N1[C@H]2Cc3cc(ccc3[C@@H]2[C@@H](CCCCC(N)=N)C1=O)-c1cccc(c1)C(=O)N(CC)CC
Structure:
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