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Target
D(2) dopamine receptor
Ligand
BDBM50079157
Substrate
n/a
Meas. Tech.
ChEMBL_60061 (CHEMBL671375)
Ki
73±n/a nM
Citation
 Carling, RW; Moore, KW; Moyes, CR; Jones, EA; Bonner, K; Emms, F; Marwood, R; Patel, S; Patel, S; Fletcher, AE; Beer, M; Sohal, B; Pike, A; Leeson, PD 1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels. J Med Chem 42:2706-15 (1999) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50079157
Synonyms:
1-(1-Benzyl-piperidin-4-yl)-4-(3-chloro-phenyl)-5-methyl-1,3-dihydro-imidazol-2-one | CHEMBL94283
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3O
Mol. Mass.:
381.898
SMILES:
Cc1c([nH]c(=O)n1C1CCN(Cc2ccccc2)CC1)-c1cccc(Cl)c1
Structure:
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