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Target
Proteinase-activated receptor 1
Ligand
BDBM50079753
Substrate
n/a
Meas. Tech.
ChEBML_209264
IC50
870±n/a nM
Citation
 Ahn, HS; Arik, L; Boykow, G; Burnett, DA; Caplen, MA; Czarniecki, M; Domalski, MS; Foster, C; Manna, M; Stamford, AW; Wu, Y Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists. Bioorg Med Chem Lett 9:2073-8 (1999) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50079753
Synonyms:
7-(4-Isopropyl-benzyl)-N*3*-methyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL305329
Type:
Small organic molecule
Emp. Form.:
C21H23N5
Mol. Mass.:
345.4408
SMILES:
CNc1nc(N)c2c3ccn(Cc4ccc(cc4)C(C)C)c3ccc2n1
Structure:
Search PDB for entries with ligand similarity: