Reaction Details Report a problem with these data
Target
H2-K region expressed gene 2, rat orthologue
Ligand
BDBM50079830
Substrate
n/a
Meas. Tech.
ChEBML_103872
IC50
45000±n/a nM
Citation
Jones, AB; Acton, JJ; Rivetna, MN; Cummings, RT; Cubbon, RM; Nichols, EA; Schwartz, CD; Wicker, LS; Hermes, JD Tetrapeptide derived inhibitors of complexation of a class II MHC: the peptide backbone is not inviolate. Bioorg Med Chem Lett 9:2109-14 (1999) [PubMed] Article
More Info.:
Target
Name:
H2-K region expressed gene 2, rat orthologue
Synonyms:
MHC class II | MHC class II region expressed gene KE2, isoform CRA_a
Type:
PROTEIN
Mol. Mass.:
14499.39
Organism:
Rattus norvegicus
Description:
ChEMBL_10342
Residue:
127
Sequence:
MAELIQKKLQGEVEKYQQLQKDLSKSMSGRQKLEAQLTENNIVKEELALLDGSNVVFKLLGPVLVKQELGEARATVGKRLDYITAEIKRYESQLRDLERQSEQQRETLAQLQQEFQRAQNAKAPGKA
Inhibitor
Name:
BDBM50079830
Synonyms:
CHEMBL414178 | [(S)-1-((S)-1-{[(S)-1-((S)-1-Carbamoyl-3-methyl-butylcarbamoyl)-butylamino]-methyl}-2-methyl-propylcarbamoyl)-2-phenyl-ethyl]-carbamic acid ethyl ester
Type:
Small organic molecule
Emp. Form.:
C28H47N5O5
Mol. Mass.:
533.7033
SMILES:
CCC[C@H](NC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCC)C(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O