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Target
Adenosine receptor A1
Ligand
BDBM50080291
Substrate
n/a
Meas. Tech.
ChEMBL_27434 (CHEMBL640188)
IC50
262±n/a nM
Citation
 Campbell, RM; Cartwright, C; Chen, W; Chen, Y; Duzic, E; Fu, JM; Loveland, M; Manning, R; McKibben, B; Pleiman, CM; Silverman, L; Trueheart, J; Webb, DR; Wilkinson, V; Witter, DJ; Xie, X; Castelhano, AL Selective A1-adenosine receptor antagonists identified using yeast Saccharomyces cerevisiae functional assays. Bioorg Med Chem Lett 9:2413-8 (1999) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50080291
Synonyms:
(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyridin-4-ylmethyl-amine | CHEMBL81863
Type:
Small organic molecule
Emp. Form.:
C20H19N5
Mol. Mass.:
329.3984
SMILES:
Cc1[nH]c2nc(nc(NCc3ccncc3)c2c1C)-c1ccccc1
Structure:
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