Reaction Details Report a problem with these data
Target
rRNA adenine N-6-methyltransferase
Ligand
BDBM50081297
Substrate
n/a
Meas. Tech.
ChEMBL_67531 (CHEMBL679968)
Ki
2000±n/a nM
Citation
Hajduk, PJ; Dinges, J; Schkeryantz, JM; Janowick, D; Kaminski, M; Tufano, M; Augeri, DJ; Petros, A; Nienaber, V; Zhong, P; Hammond, R; Coen, M; Beutel, B; Katz, L; Fesik, SW Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis. J Med Chem 42:3852-9 (1999) [PubMed] Article
More Info.:
Target
Name:
rRNA adenine N-6-methyltransferase
Synonyms:
ERM_STREE | ErmAM | Macrolide-lincosamide-streptogramin B resistance protein | erm
Type:
PROTEIN
Mol. Mass.:
28804.82
Organism:
Streptococcus pneumoniae
Description:
ChEMBL_67532
Residue:
245
Sequence:
MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKLNIRVTLIHQDILQFQFPNKQRYKIVGSIPYHLSTQIIKKVVFESHASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTITYEQVLSIFNSYLLFNGRK
Inhibitor
Name:
BDBM50081297
Synonyms:
1-[4-Amino-6-(indan-2-ylamino)-[1,3,5]triazin-2-yl]-piperidine-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-amide | CHEMBL340522
Type:
Small organic molecule
Emp. Form.:
C28H32N8O
Mol. Mass.:
496.6067
SMILES:
Nc1nc(NC2Cc3ccccc3C2)nc(n1)N1CCC(CC1)C(=O)NCCc1c[nH]c2ccccc12