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TargetCoagulation factor X
LigandBDBM50081365
Substrate/Competitorn/a
Meas. Tech.ChEMBL_49161
Ki 12±n/a nM
Citation McDowell, LMMcCarrick, MAStudelska, DRGuilford, WJArnaiz, DDallas, JLLight, DRWhitlow, MSchaefer, J Conformations of trypsin-bound amidine inhibitors of blood coagulant factor Xa by double REDOR NMR and MD simulations. J Med Chem42:3910-8 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50081365
NameBDBM50081365
Synonyms:3-(5-{3-[(Z)-amino(imino)methyl]phenoxy}-2,4-difluoro-3-methylphenoxy)benzenecarboximidamide | CHEMBL126575
TypeSmall organic molecule
Emp. Form.C21H18F2N4O2
Mol. Mass.396.39
SMILESCc1c(F)c(Oc2cccc(c2)C(N)=N)cc(Oc2cccc(c2)C(N)=N)c1F
Structure
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n/a