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Target
Neuronal acetylcholine receptor subunit alpha-10
Ligand
BDBM50081496
Substrate
n/a
Meas. Tech.
ChEBML_142761
Ki
>10000±n/a nM
Citation
 Lin, NH; Abreo, MA; Gunn, DE; Lebold, SA; Lee, EL; Wasicak, JT; Hettinger, AM; Daanen, JF; Garvey, DS; Campbell, JE; Sullivan, JP; Williams, M; Arneric, SP Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework. Bioorg Med Chem Lett 9:2747-52 (1999) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-10
Synonyms:
ACH10_RAT | Chrna10 | Neuronal acetylcholine receptor protein alpha-10 subunit | Nicotinic acetylcholine receptor alpha9/alpha10
Type:
PROTEIN
Mol. Mass.:
49830.54
Organism:
Rattus norvegicus
Description:
ChEMBL_143222
Residue:
447
Sequence:
MGTRSHYLDLGFLLLLFLPAECLGAEGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWDPKAYGDLDAIRIPSRLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRPRGTSASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLILAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAWARVLLLGHLAKGLCVRERGEPCGQSKPLESAPSLQPPPASPAGPCHEPRCLCHQEALLHHIASIASTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVMSLIVLVQAL
  
Inhibitor
Name:
BDBM50081496
Synonyms:
5-((S)-1-Azetidin-2-ylmethoxy)-pyrimidine | CHEMBL328705
Type:
Small organic molecule
Emp. Form.:
C8H11N3O
Mol. Mass.:
165.1924
SMILES:
C(Oc1cncnc1)[C@@H]1CCN1
Structure:
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