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Target
Bile salt-activated lipase
Ligand
BDBM50081695
Substrate
n/a
Meas. Tech.
ChEMBL_48915 (CHEMBL660745)
Ki
580±n/a nM
Citation
 Deck, LM; Baca, ML; Salas, SL; Hunsaker, LA; Vander Jagt, DL 3-Alkyl-6-chloro-2-pyrones: selective inhibitors of pancreatic cholesterol esterase. J Med Chem 42:4250-6 (1999) [PubMed]  Article 
Target
Name:
Bile salt-activated lipase
Synonyms:
BAL | CEL | CEL_HUMAN | Cholesterol esterase
Type:
PROTEIN
Mol. Mass.:
79308.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_512655
Residue:
753
Sequence:
MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIRF
  
Inhibitor
Name:
BDBM50081695
Synonyms:
6-Chloro-3-(4-cyclohexyl-butyl)-pyran-2-one | CHEMBL135278
Type:
Small organic molecule
Emp. Form.:
C15H21ClO2
Mol. Mass.:
268.779
SMILES:
Clc1ccc(CCCCC2CCCCC2)c(=O)o1
Structure:
Search PDB for entries with ligand similarity: