Reaction Details Report a problem with these data
Target
Glutathione S-transferase omega-1
Ligand
BDBM50527165
Substrate
n/a
Meas. Tech.
ChEMBL_1902458 (CHEMBL4404680)
Ki
9600±n/a nM
Citation
 Xie, Y; Tummala, P; Oakley, AJ; Deora, GS; Nakano, Y; Rooke, M; Cuellar, ME; Strasser, JM; Dahlin, JL; Walters, MA; Casarotto, MG; Board, PG; Baell, JB Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors. J Med Chem 63:2894-2914 (2020) [PubMed]  Article 
Target
Name:
Glutathione S-transferase omega-1
Synonyms:
GSTO 1-1 | GSTO1 | GSTO1_HUMAN | GSTTLP28 | Glutathione S-transferase omega-1 | Glutathione transferase omega 1 | glutathione S-transferase omega-1 isoform 1
Type:
PROTEIN
Mol. Mass.:
27565.54
Organism:
Homo sapiens (Human)
Description:
EBI_11172
Residue:
241
Sequence:
MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKPEWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELFSKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPWFERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYGL
  
Inhibitor
Name:
BDBM50527165
Synonyms:
CHEMBL4554461
Type:
Small organic molecule
Emp. Form.:
C9H11ClFNO4S2
Mol. Mass.:
315.769
SMILES:
CN(C)S(=O)(=O)c1cc(CS(F)(=O)=O)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: