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Target
B2 bradykinin receptor
Ligand
BDBM50409120
Substrate
n/a
Meas. Tech.
ChEMBL_40443 (CHEMBL652382)
Ki
0.6±n/a nM
Citation
 Dziadulewicz, EK; Ritchie, TJ; Hallett, A; Snell, CR; Ko, SY; Wrigglesworth, R; Hughes, GA; Dunstan, AR; Bloomfield, GC; Drake, GS; Brown, MC; Lee, W; Burgess, GM; Davis, C; Yaqoob, M; Perkins, MN; Campbell, EA; Davis, AJ; Rang, HP 1-(2-Nitrophenyl)thiosemicarbazides: a novel class of potent, orally active non-peptide antagonist for the bradykinin B(2) receptor. J Med Chem 43:769-71 (2000) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BK-2 receptor | BKRB2_RAT | Bdkrb2 | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44941.22
Organism:
RAT
Description:
B2 BRADYKININ BDKRB2 RAT::P25023
Residue:
396
Sequence:
MDTRSSLCPKTQAVVAVFWGPGCHLSTCIEMFNITTQALGSAHNGTFSEVNCPDTEWWSWLNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWSCTLLLSSPMLVFRTMKDYREEGHNVTACVIVYPSRSWEVFTNMLLNLVGFLLPLSIITFCTVRIMQVLRNNEMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTLLRLGVLSGCWNERAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGGCMGESVQMENSMGTLRTSISVDRQIHKLQDWAGNKQ
  
Inhibitor
Name:
BDBM50409120
Synonyms:
CHEMBL2112044 | CHEMBL2112937
Type:
Small organic molecule
Emp. Form.:
C32H42N8O5S2
Mol. Mass.:
682.856
SMILES:
CN(C)CCN(C)CCNC(=O)C1CCCN1S(=O)(=O)c1ccc(NN\C([S-])=[NH+]\C(c2ccccc2)c2ccccc2)c(c1)[N+]([O-])=O
Structure:
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