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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50085751
Substrate
n/a
Meas. Tech.
ChEMBL_71751 (CHEMBL680273)
Ki
0.35±n/a nM
Citation
 Rivier, JE; Porter, J; Cervini, LA; Lahrichi, SL; Kirby, DA; Struthers, RS; Koerber, SC; Rivier, CL Design of monocyclic (1-3) and dicyclic (1-3/4-10) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem 43:797-806 (2000) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50085751
Synonyms:
CHEMBL437230 | cyclo(1,1'-3)Ac-D-Asp (beta-Ala)-D-Cpa-D-Dpr-Ser-Tyr-D-Nal-Leu-Arg-Pro-D-Ala-NH2
Type:
Small organic molecule
Emp. Form.:
C66H87ClN16O15
Mol. Mass.:
1379.948
SMILES:
CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)NCCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Structure:
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