Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50085963
Substrate
n/a
Meas. Tech.
ChEMBL_221212 (CHEMBL842437)
IC50
12000±n/a nM
Citation
 Malamas, MS; Sredy, J; Gunawan, I; Mihan, B; Sawicki, DR; Seestaller, L; Sullivan, D; Flam, BR New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties. J Med Chem 43:995-1010 (2000) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_RAT | PTP-1B | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Ptpn1 | Tyrosine-protein phosphatase, non-receptor type 1
Type:
Enzyme
Mol. Mass.:
49669.91
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
432
Sequence:
MEMEKEFEQIDKAGNWAAIYQDIRHEASDFPCRIAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLKCAQYWPQKEEKEMVFDDTNLKLTLISEDVKSYYTVRQLELENLATQEAREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHVPPPPRPPKRTLEPHNGKCKELFSNHQWVSEESCEDEDILAREESRAPSIAVHSMSSMSQDTEVRKRMVGGGLQSAQASVPTEEELSPTEEEQKAHRPVHWKPFLVNVCMATALATGAYLCYRVCFH
  
Inhibitor
Name:
BDBM50085963
Synonyms:
2-{(E)-3-[3-(3,5-Bis-trifluoromethyl-phenoxymethyl)-phenyl]-but-2-enyl}-[1,2,4]oxadiazolidine-3,5-dione | 2-{3-[3-(3,5-Bis-trifluoromethyl-phenoxymethyl)-phenyl]-but-2-enyl}-[1,2,4]oxadiazolidine-3,5-dione | CHEMBL7084
Type:
Small organic molecule
Emp. Form.:
C21H16F6N2O4
Mol. Mass.:
474.3532
SMILES:
C\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(COc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1
Structure:
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