Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50086117
Substrate
n/a
Meas. Tech.
ChEMBL_843 (CHEMBL615406)
IC50
700±n/a nM
Citation
 Matzen, L; van Amsterdam, C; Rautenberg, W; Greiner, HE; Harting, J; Seyfried, CA; Böttcher, H 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants. J Med Chem 43:1149-57 (2000) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50086117
Synonyms:
1-{2-[4-(6-fluoro-1H-indol-3-yl)piperidin-1yl]ethyl}-[2,3-Dihydro-1'-methylspiro(benzofuran-3,4'-piperidine)]-amide | CHEMBL15909
Type:
Small organic molecule
Emp. Form.:
C29H36FN5O2
Mol. Mass.:
505.6268
SMILES:
CN1CCC2(COc3ccc(NC(=O)NCCN4CCC(CC4)c4c[nH]c5cc(F)ccc45)cc23)CC1
Structure:
Search PDB for entries with ligand similarity: