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TargetSerotonin 1B/1D receptor
LigandBDBM50086115
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1774
IC50 23±n/a nM
Citation Matzen, Lvan Amsterdam, CRautenberg, WGreiner, HEHarting, JSeyfried, CABöttcher, H 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants. J Med Chem43:1149-57 (2000) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serotonin 1B/1D receptor
Name:Serotonin 1B/1D receptor
Synonyms:5-HT-1B | 5-HT1B | 5-hydroxytryptamine receptor 1B (5HT1B) | Serotonin 1 (5-HT1) receptor | Serotonin receptor 1B
Type:Protein
Mol. Mass.:43173.33
Organism:Rattus norvegicus (Rat)
Description:P28564
Residue:386
Sequence:
MEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATT
LSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDF
WLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPP
FFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTP
NKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKL
MAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLI
NPIIYTMSNEDFKQAFHKLIRFKCTG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50086115
NameBDBM50086115
Synonyms:5-[4-(5-fluoro-1H-3-indolyl)hexahydro-1-pyridinylcarboxamido]-1'-methylspiro[2,3-dihydrobenzo[b]furan-3,4'-(hexahydropyridine)] | CHEMBL276928
TypeSmall organic molecule
Emp. Form.C27H31FN4O2
Mol. Mass.462.559
SMILESCN1CCC2(COc3ccc(NC(=O)N4CCC(CC4)c4c[nH]c5ccc(F)cc45)cc23)CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a